Скачать или смотреть The Institute of Cannabis Research (ICR) at Colorado State University-Pueblo: Institute activities..

#isams #acupuncture #internationalconference
Abstract: The institute of Cannabis Research was established in 2016 through a unique partnership between Colorado State University-Pueblo, the State of Colorado, and Pueblo County. The mission of the ICR is to generate new knowledge and understanding of cannabis through innovative research, education, and dissemination of results and information. This presentation will include background information on the ICR and its activities, a discussion of trends in cannabis research in the United States, and results from some research projects supported through the ICR. The first project focuses the development of an efficient extraction method for the recovery of the cannabinoid cannabidiol from industrial hemp using pressurized liquid extraction. This unique PLE method includes a dual extraction process in which the hemp undergoes a pre-extraction with water to promote decarboxylation of cannabidiolic acid to CBD, without significant loss of neutral cannabinoids, followed by PLE using ethanol to extract the CBD. This PLE method can be employed to efficiently carry out decarboxylation of other acidic cannabinoids to their neutral counterparts. A second project that will be discussed is an interrupted time series analysis was conducted to assess the impact of Colorado’s legalization of both medical and recreational cannabis over the time period 1999 -- 2018. Both were associated with a reduction of opioid overdose mortality rates. This reduction represents a reversal of the upward trend in opioid-related deaths in Colorado. The final projects that will be discussed aim at showing mechanisms which underlie effects of various cannabinoids on learning and memory in a rodent model. Our published results have shown prominent effects of Cannabidiol on the fundamental mechanisms of learning and memory, and work in progress is showing similar effects of HU-211, a synthetic glutamate receptor inhibitor. This basic medical research involves behavioral, pharmacological, electrophysiological and histological methods and has relevance for understanding appropriate medical applications for cannabinoids to treat brain disorders ranging from Alzheimer’s disease to Post Traumatic Stress Disorder.