Cholinergic Agonists Acetylcholine Neostigmine Parathion

Cholinergic agonists are a class of drugs that mimic the action of acetylcholine, a neurotransmitter in the nervous system. These drugs activate cholinergic receptors, leading to various effects such as increased muscle contraction, enhanced glandular secretions, and slowed heart rate. Cholinergic agonists are used therapeutically to treat conditions like glaucoma, urinary retention, and dry mouth. However, they can also cause side effects like excessive sweating, bradycardia, and gastrointestinal distress. Understanding their mechanism of action is crucial for their safe and effective use in clinical practice.

Timecodes
0:00 Intro
2:01 Synthesis and release of Acetylcholine
9:37 Cholinergic Agonists Category
15:43 Cholinoceptors Characteristics
19:29 Cholinoceptors Distribution
21:08 Muscarinic receptors
22:29 Acetylcholine (Ach)-muscarinic actions
27:50 Nicotinic receptors
30:12 Mnemonic that captures the muscarinic effects
31:08 Direct-acting (Cholinomimetic Agents)
38:35 Direct-acting cholinomimetic agents Table
39:57 Adverse Effects of Cholinergic Agonists
41:36 Pharmacologic targets in the eye
44:36 Anticholinesterases (Reversible)
46:00 Acetylcholinesterase (AChE)
46:34 AChEIs Image and list of agents
55:38 Physostigmine vs. Neostigmine
57:05 Myasthenia Gravis
57:53 Alzheimer disease Treatment
1:01:24 Anticholinesterases (Irreversible)
1:03:21 Major Signs and Symptoms of Organophosphate Insecticide Poisoning
1:06:06 How to treat organophosphate toxicity