Скачать или смотреть Incucyte® Webinar Preview: Live Cell Analysis of Human Neuron Glial Cell Co Cultures

Modulation of glial cell activity and/or neuron-glia communication presents an interesting therapeutic approach for several neurodegenerative/neuropsychiatric conditions.

There is a need for disease-relevant, fully human, predictive models, to support the preclinical development of new medicines, targeting different areas of neurodegenerative disease. Elucidating these complex pathways requires robust model systems, to enable testing and development of novel molecules.

This webinar includes discussion on: -The generation and characterization of human iPSC-derived neurons and glia in mono and co-culture --An explanation of how the presence of glia can influence neuronal network maturation and activity --How complex cell-based models combined with live-cell analysis, can provide insights into disease-relevant biology.

Watch the full webinar: https://www.sartorius.com/en/products...

0:17 microglial dysfunction is strongly implicated in the progression of multiple neurological diseases such as Alzheimer's disease and schizophrenia often leading to neuroinflammation which can ultimately lead to neuronal death

0:33 if we have a closer look at that using the inky side platform from Sartorius where we're able to really nicely show that human ipsc derived neuronal cultures mature over time to form functionally active neuronal networks which is obviously an important thing to be able to observe

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