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Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins - a 2 minute Preview of the Experimental Protocol

Pingan Yuanxiang, Sujoy Bera, Anna Karpova, Michael R. Kreutz, Marina Mikhaylova
Leibniz Institute for Neurobiology, RG Neuroplasticity; Utrecht University, Department of Cell Biology;

We provide a detailed protocol for induction of long-term potentiation in the CA1 region of the hippocampus and the subsequent isolation of nuclear enriched fractions from the tetanized area of the slice. This approach can be used to determine activity dependent nuclear protein import in cellular models of learning and memory.

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