Скачать или смотреть Sequencing HER2+ therapies in breast cancer: insights on ADCs, TKIs, chemo, & maintenance strategies

Erika Hamilton, MD, Sarah Cannon Research Institute, Nashville, TN, explores how clinicians can navigate sequencing decisions in HER2+ breast cancer with expanding options including antibody-drug conjugates (ADCs) like trastuzumab deruxtecan, tyrosine kinase inhibitors (TKIs) such as tucatinib, and chemotherapy-based regimens. Emerging data from PATINA (NCT02947685) and HER2CLIMB-05 (NCT05132582) highlight the growing role of maintenance strategies, while differences in patient populations across trials underscore the importance of clinical context. As new results like DESTINY-Breast09 (NCT04784715) evolve, maintenance therapy may become central regardless of first-line induction choice. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2025 Meeting in San Antonio, TX.

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