Скачать или смотреть Scientists from IOCB Prague help to improve medical drugs

Researchers from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences are furthering the understanding of how medicines work and what it takes to develop their most effective variants.

In one current study, they have focused on the disease caused by the protozoan parasite Trichomonas vaginalis, especially because of the recent appearance of strains that are resistant to conventional treatment. In an effort to find a new weak spot of this parasite, the research group led by Dr. Evžen Bouřa has succeeded in preparing a key enzyme complex – the proteasome.

This has made it possible to gain knowledge that is indispensable for the development of new effective medicines. The research was carried out in collaboration with colleagues from the University of California San Diego. An article presenting the work has been published in the scientific journal Nature Communications.

Česká verze ►    • Výzkum vědců z ÚOCHB pomáhá vylepšovat úči...   ⤵
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Original article: Silhan, J.; Fajtova, P.; Bartosova, J.; Hurysz, B. M.; Almaliti, J.; Miyamoto, Y.; Eckmann, L.; Gerwick, W. H.; O’Donoghue, A. J.; Boura, E. Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors. Nat. Commun. 2024, 15, 8621. https://doi.org/10.1038/s41467-024-53...