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SUPRASPINAL AND SPINAL EFFECTS OF GROUP I AND III METABOTROPIC GLUTAMATE RECEPTOR AGONISTS ON THE MICTURITION REFLEX IN RATS

Honda M1, Teraoka S1, Kimura Y1, Panagiota T1, Shimizu S2, Shimizu T2, Morizane S1, Hikita K1, Saito M2, Takenaka A1

1. Department of Urology, Tottori University Faculty of Medicine, 2. Department of Pharmacology, Kochi Medical School

KEYWORDS: Animal Study, Basic Science, Physiology

The modulatory effects of glutamate, the main excitatory neurotransmitter in the central nervous system, are mediated by the activation of metabotropic glutamate receptors (mGluRs) [1]. Eight distinct mGluRs (mGluR1−8) have been classified into three groups (I−III) according to their sequence homology [2]. Group I (mGluRI; mGluR1 and mGluR5), group II (mGluRII: mGluR2 and mGluR3), and group III (mGluRIII: mGluR4, mGluR6, mGluR7, and mGluR8) mGluRs are widely distributed throughout the central nervous system [3]. However, the role of mGluRs in the regulation of neural mechanisms controlling the micturition reflex remains unknown. In the present study, we assessed whether RS-3,5-dihydroxyphenylglycine (RS-3,5-DHPG), a selective mGluRI agonist; 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC), a selective mGluRII agonist; and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4), a selective mGluRIII agonist, affect the micturition reflex in urethane-anaesthetized rats.

Read the full abstract text here: https://www.ics.org/2020/abstract/274