Isotretinoin capsules ip 10 mg uses in hindi | Isotretinoin capsules ip 20 mg side effects in hindi

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Isotretinoin capsule contains Isotretinoin which belongs to the group of medicines called Retinoids. It is used to treat severe form of acne (such as nodular acne, conglobate acne, and acne that is at risk of permanent scarring), which has not improved after other anti-acne treatments.




MODE OF ACTION
Isotretinoin reduces the sebaceous gland size and sebum production during acne treatment. In neuroblastoma, it decreases cell proliferation and induces differentiation.




GENERAL CONSIDERATIONS


• Oral: Administer standard formulation with a meal; lidose or micronized formulations may be taken without regard to meals. Capsules should be swallowed whole with a full glass of liquid; do not chew or suck on the capsule. For patients unable to swallow capsule whole, an oral liquid may be prepared to irritate the esophagus if contents are removed from the capsule. Safety of once daily dosing of Isotretinoin (systemic) has not been established and is not recommended.
• Standard formulations are not bioequivalent to lidose or micronized formulations. Lidose and micronized formulations are not substitutable with one another due to differences in bioavailability.
• Advise patients to limit intake of vitamin A and avoid use of other vitamin A products. Some formulations may contain soybean oil.
• Advise patients to avoid prolonged exposure to UV rays or sunlight.
• Instruct patients to avoid or limit ethanol; triglyceride levels may be increased if taken in excess.
• Isotretinoin and tretinoin (which is also known as all-trans retinoic acid, or ATRA) may be mistaken for each other; while both products may be used in cancer treatment, they are not interchangeable. Verify the product prior to dispensing and administration to prevent medication errors.
• Patients should be warned against donating blood during therapy and for 1 month following discontinuation of therapy due to the risk of donated blood being given to a pregnant patient.
• Isotretinoin (systemic) should only be prescribed by healthcare providers competent in treating severe, recalcitrant, nodular acne and experienced with the use of systemic retinoids.
Safety of long-term use is not established and is not recommended; the effect on bone loss is unknown.
• Avoid skin-resurfacing procedures (e.g. dermabrasion and laser) and wax epilation during therapy and for ≥6 months after discontinuation of Isotretinoin due to the risk of scarring.
• Advise female patients to avoid pregnancy during the treatment.




COMMON BRAND NAMES
Absorica, Absorica LD, Accutane, Amnesteem, Claravis,MYORISAN,ZENATANE,Sotret,Isotroin, Tretiva,acutret,Tretiniso,isotane,Isoin,Tufacne,Resoten




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