Скачать или смотреть Antidiabetic drugs pharmacology, sulfonylureas pharmacology, clinical pharmacology diabetes

✅ Sulfonylureas are a class of oral hypoglycemic agents used in the management of type 2 diabetes mellitus. They work primarily by stimulating insulin secretion from the pancreatic β-cells, leading to a reduction in blood glucose levels.

✅ Mechanism of Action → Stimulate pancreatic beta cells to release insulin.
✅ Common Side Effects → Hypoglycemia, weight gain.
✅ High-Risk Patients → Elderly, renal impairment, liver disease.
✅ Preferred in Renal Impairment → Gliclazide, Glipizide (shorter half-life).
✅ Highest Risk of Hypoglycemia → Glyburide (long half-life).
✅ Metabolism → CYP2C9 (drug interactions possible).
✅ Contraindications → Type 1 diabetes, severe hepatic or renal failure.
✅ Alternative for Hypoglycemia-Prone Patients → Metformin, DPP-4 inhibitors, or SGLT-2 inhibitors.
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Chapters:
0:00 - sulfonylureas pharmacology
0:16 - sulfonylureas clinical pharmacology
0:24 - sulfonylureas and hypoglycemia risk
0:44 - sulfonylureas and weight gain
1:05 - sulfonylureas long term efficacy
1:27 - sulfonylureas and renal function
1:45 - sulfonylureas administration time
2:07 - sulfonylureas pharmacology summary

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