Скачать или смотреть Serum Transferrin Receptor (sTfR) Test. Serum Transferrin Receptor and Its Ratio to Serum Ferritin

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The serum transferrin receptor (sTfR) test measures the concentration of receptor proteins in the blood, reflecting cellular iron needs, particularly to distinguish iron deficiency anemia from anemia of chronic disease. It rises when iron is low and is unaffected by inflammation, unlike ferritin. It is often paired with, but distinct from, transferrin saturation (TSAT), which measures iron binding capacity.
Key Details About Serum Transferrin Receptor (sTfR) Testing
Purpose: The sTfR test indicates how aggressively body cells are trying to take up iron.
Significance: Increased sTfR levels indicate that the body is in an iron-deficient state and attempting to increase absorption.
Advantage in Diagnosis: Unlike ferritin, which can be falsely elevated by inflammation, sTfR remains high in iron deficiency, making it effective for identifying anemia in patients with chronic infections or inflammatory diseases.
Comparison to Other Tests:
sTfR: Measures current tissue-level iron demand (rises when low).
Serum Ferritin: Measures stored iron (decreases when low).
Transferrin Saturation (TSAT): Measures iron bound to transport protein (decreases below 15-20% in deficiency).
When It Is Ordered: Used for diagnosing iron deficiency, distinguishing iron deficiency anemia from chronic disease, and monitoring response to iron therapy.
Normal vs. Abnormal Values
High sTfR: Indicates iron deficiency, increased red blood cell production, or hemolytic anemia.
Low/Normal sTfR: Usually indicates sufficient iron storage, but sTfR does not decrease with iron overload. A serum transferrin saturation (TSAT) test measures the percentage of the iron-transport protein transferrin that is bound to iron, indicating how much iron is available for bodily processes. It is a key indicator of iron deficiency (low TSAT) or overload conditions like hemochromatosis (high TSAT). Generally, 20%-50% is considered normal.
Key Aspects of the Test:
Purpose: Evaluates iron metabolism, usually ordered to diagnose anemia, iron deficiency, or iron overload.
Soluble Transferrin Receptor sTfR plays an important role in your body. It helps in the uptake of iron from a protein called Transferrin. This test is recommended to help differentiate between anemia due to iron deficiency and anemia caused by chronic diseases. sTfR is derived from developing red blood cells (Erythropoiesis). This test is specially useful as an indicator of the iron status in your body when the iron stores are empty sTfR levels high). The serum transferrin receptor (sTfR) to log ferritin index (sTfR/F index) is a highly sensitive,, diagnostic ratio used to distinguish true iron deficiency anemia (IDA) from anemia of chronic disease (ACD)
Key Aspects of the Test
Purpose: The sTfR/F index is used when serum ferritin is misleadingly normal or elevated due to inflammation, infection, or liver disease.
Sensitivity: This index has much higher sensitivity (up to 88% in some studies) compared to routine iron tests (16% in elderly populations).
Interpretation:
High Ratio Indicates increased cellular iron demand, suggesting severe depletion of iron stores (low ferritin, high sTfR).
Low Ratio Suggests iron stores are sufficient or that low serum iron is due to inflammation (ACD) rather than depletion, as ferritin remains elevated.
Components of the Ratio
Serum Transferrin Receptor (sTfR): Reflects functional iron demand; it increases in response to iron deficiency.
Serum Ferritin: Reflects total body iron stores; it is low in IDA but high as an acute-phase reactant during inflammation.
Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency
Utility of sTFR/Ferritin index to differentiate iron deficiency anaemia and anaemia of chronic diseaseIron deficiency is a common condition that is usually diagnosed using conventional laboratory tests of iron status, such as serum ferritin and transferrin saturation. However, both ferritin and transferrin proteins are markedly influenced by inflammation, behaving as acute-phase reactants and making it difficult to differentiate between iron-deficiency anemia (IDA) and anemia of chronic disease (ACD).Level of sTfR is markedly elevated in Iron deficiency anaemia but remains normal in anemia due to chronic inflammation without iron deficiency. Thus levels of sTfR may be of considerable help in differentiating between Iron deficiency anaemia and Anemia of chronic disease. In addition, use of the formula sTfR/log ferritin ratio may increase the efficacy of sTfR in identifying Iron deficiency anaemia and Anaemia of chronic disease.