Menin inhibition in relapsed/refractory AML: what do the data tell us?

During the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub was pleased to speak to Ghayas Issa, MD Anderson Cancer Centre, Houston, US. We asked, What do the data tell us about menin inhibition in relapsed/refractory acute myeloid leukemia (AML)?

Issa explains the mechanism of action of menin inhibitors, then goes on to describe the positive findings from phase I studies of ziftomenib and revumenib in relapsed/refractory AML, including for patients with NPM1 mutations and KMT2A rearrangements. Issa also discusses data for a subset of patients treated with revumenib who underwent hematopoietic stem cell transplantation and outlines plans for combination studies of menin inhibitors with other agents.