Скачать или смотреть [App Note] Microfluidics for Alginate Microbeads Production - Fluigent

You want to produce alginate beads? Or you are already doing microencapsulation?
Don’t forget to share your question/experience in the comments! We will be happy to discuss it with you!
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How to produce alginate beads using the microfluidic method?
Microencapsulation has been one of the most interesting fields in the area of pharmaceutical technology since its inception many years ago.
Microencapsulation products (microparticles, microbeads) are small entities that contain an active agent or core material surrounded by a shell or embedded into a matrix structure.
Among all these materials, alginate is a good candidate for many applications. Alginate spheres are one of the most widely investigated cell encapsulation materials as they are biocompatible, nontoxic, biodegradable, and relatively inexpensive.
Their structural similarity to the extracellular matrices of living tissues allows for applications in wound healing, delivery of bioactive agents such as small chemical drugs and proteins, and cell transplantation.

Alginate microbeads are widely used in pharmaceutical research, tissue engineering, and regenerative medicine.
Although the production of alginate microbeads appears to be a successful drug delivery system, it is often hindered by technical challenges, mainly associated with high viscosity of polymer fluids. Many methods are used for encapsulation of agents (bacteria, pancreatic islets, API) in microbeads, such as extrusion, batch method, spray drying…
The most widespread method for producing alginate microbeads is extrusion, where a solution of alginate is injected through a needle into a calcium bath to produce ionically crosslinked beads.
This easy to use method allows one to produce alginate microbeads which have a wide size distribution, without possible automation and no control over the bead size. This is a big limitation because in microbead production, particle size is key parameter.

As the reproducibility and throughput of such methods is low, there is demand for better techniques and control of the process to produce alginate microbeads.
Droplet-based microfluidics, offers an efficient method for improvement of this process. It is a powerful tool which enables the production of micrometric size monodispersed droplets.

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https://www.fluigent.com/applications...

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