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E2 Elimination: Predicting Zaitsev vs Hofmann

1. Small strong base favors Zaitsev
2. Bulky base favors Hofmann
3. Pull H from adjacent carbon
4. More substituted alkene is more stable
5. Steric hindrance limits base access
6. Check antiperiplanar alignment for elimination

Predicting Zaitsev vs Hofmann Outcomes

1. Assuming Zaitsev always forms
2. Ignoring substrate steric hindrance effects
3. Forgetting antiperiplanar alignment requirement

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