Restrictive Lung Diseases - Interstitial Pulmonary Fibrosis. Pathology, Clinical, Tests, Treatment

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This video presents the introduction to restrictive lung diseases. We will discuss: 
Definition
Types 
Extrapulmonary restrictive lung diseases
Obesity
Scoliosis
Pulmonary parenchymal restrictive lung diseases
Idiopathic
Autoimmune
Granulomatous (Wagner's granulomatosis, Sarcoidosis)
Occupational (pneumoconiosis, silicosis, asbestosis, coal, etc.)
Other irritants
Chronic infections (Tuberculosis)
Neuromuscular restrictive lung diseases
Myasthenia gravis
Diaphragm issues
Polio
Cellular events/pathogenesis
Damaged Type I Pneumocytes
Hypertrophy of Type II Pneumocytes
Irritated epithelium
Irritated macrophages
Apoptosis of epithelium
Tissue damage leading to local inflammation and lung destruction/scaring.
Neutrophils releasing cytokines, proteases, tumor growth factors (TGF)
Macrophages releasing transforming growth factor beta, tumor necrosis factor (TNF), platelet activation factor.
Fibroblasts overactivity resulting in more extracellular matrix and hardening.
Epithelial-mesenchymal transformation.
Smooth muscle proliferation.
Respiratory interface thickening. Disrupted gaseous exchange.
Clinical:
Dry hacking cough
Dyspnea
Hypoxia
Respiratory alkalosis
Late inspiratory crackles
Abnormal chest X-Ray
Reduced volume in chest X-Ray
Lower lobes show more involvement and the reason why.
Right heart failure/cor pulmonale 
Lung Function Changes
FEV1/FVC ratio increases above 80% (normal or above normal)
Treatment
Anti-inflammatory (may not be very effective)
TGF Beta-blockers
Oxygen
Lung transplant ...

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.