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The 27 Club includes popular musicians, artists, actors, and athletes who have died at age 27, often as a result of drug and alcohol abuse or violent means such as homicide, suicide, or transportation-related accidents. The deaths of several 27-year-old popular musicians between 1969 and 1971 led to the belief that deaths are more common at this age. Statistical studies have failed to find any unusual pattern of musician deaths at this age, comparing it to equally small increases at ages 25 and 32, with a 2011 BMJ study noting instead that young adult musicians have a higher death rate than the rest of the young adult population, concluding: "Fame may increase the risk of death among musicians, but this risk is not limited to age 27".

The "club" has been repeatedly cited in music magazines, journals and the daily press. Several exhibitions have been devoted to the idea, as well as novels, films and stage plays. There have been many theories and speculations about the causes of such early deaths and their possible connections. Four years before the BMJ study was published, Cobain and Hendrix biographer Charles R. Cross wrote: "The number of musicians who died at 27 is truly remarkable by any standard. [Although] humans die regularly at all ages, there is a statistical spike for musicians who die at 27."