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This clip is from episode #357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.

In this clip, they discuss:

Hallmarks vs. Pillars of Aging – While frameworks like “hallmarks” and “pillars” of aging provide structure, they don't explain the true cause of aging, as everything is highly interconnected
Interconnected Pathways Over Isolated Targets – Interventions like rapamycin affect multiple hallmarks, highlighting that aging is a network of interdependent processes, not separate targets
Aging Is About Homeostasis – Healthy aging is framed as the body’s ability to maintain balance and respond to damage, rather than targeting individual biological changes
Inflammation as a Central Player – In experiments, inflammation consistently emerges as a strong signal tied to aging and longevity interventions, showing up in aging clocks and biomarker analysis
Causality Between Hallmarks Is Unclear – The discussion debates whether mitochondrial dysfunction causes epigenetic changes or vice versa, reflecting the challenge in defining primary drivers

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