BACTERIA INFECTION CAUSES 1/5 GLOBAL DEATH! EJW science research. Edwin Williams.

Significance of Drug Resistant infection and Sepsis.
A recent research study estimated that there were more than 10 million sepsis related deaths in 2017, indicating that infections were involved in more than 20% of deaths globally for that year. Sepsis is body’s extreme response to an infection that spreads all over the body which is difficult to control and leads to organ damage and death if not immediately treated.
Research studies have estimated that drug-resistant infections and sepsis are leading causes of death globally. Reducing these deaths have become urgent global health priority. The study of Dr. K.S. Ikuta of California and a plethora of scientists around the world is the first to present global comprehensive estimates of deaths from 33 bacterial pathogens across 11 major infectious syndromes. From an estimated 13·7 million infection-related deaths in 2019, 7·7 million deaths were due to these 33 bacterial pathogens.
The team conducted collaborative research world-wide and estimated deaths associated with those bacterial genera or species across 11 infectious syndromes in 2019 on 343 million individual records or isolates in 11, 361 study-location. They studied i) number of deaths from those pathogens, ii) deaths in which infection had a role, and iii) deaths due to an infectious syndrome that were attributable to a given pathogen. The study found that 13·6% of all global deaths and 56·2% of all sepsis-related deaths in 2019 were from those five leading pathogens—Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Mortality rate associated with those bacterial pathogens was highest in the sub-Saharan Africa, and lowest in the high-income regions. Staphylococcus aureus was the leading bacterial cause of death in 135 countries and was also associated with most deaths in individuals older than 15 years. Among children younger than 5 years, Streptococcus pneumoniae was the pathogen associated with most deaths.
Those 33 bacterial pathogens the team investigated in the study were a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations which should be considered as an urgent priority for intervention within the global health community.
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Ref: K S Ikuta et al., The Lancet 400, 10369 P2221-2248 Dec 2022