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DNA chimerism occurs when an individual has two or more distinct sets of DNA within their body. This rare phenomenon can form in various ways, such as when two embryos fuse early in development or when an individual absorbs genetic material from a twin, a sibling in the womb, or even their own offspring during pregnancy. As a result, different tissues in the body can carry different genetic codes.

In cases of chimerism, the DNA in a person’s blood might differ from the DNA in other tissues, such as the cervix or ovaries. This discrepancy can lead to surprising results, such as a mother’s blood DNA not matching the DNA of her children. Since her children are created using the DNA from her ovaries or pelvic tissues, the mismatch occurs if the blood contains DNA from a different genetic source. These scenarios underscore the complexities of genetics and how unique biological events can shape a person’s genetic identity.

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