Скачать или смотреть 💊 H2 Antihistamines Pharmacology USMLE ! Ranitidine, Famotidine, Cimetidine | Dr.G. Bhanu Prakash

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💊 H2 Antihistamines Made Easy! Ranitidine, Famotidine, Cimetidine | High-Yield Pharma for USMLE

H2 Antihistamines are a crucial drug class in the management of acid-related GI disorders and are frequently tested in NEET PG, FMGE, and USMLE pharmacology questions. 🧪💊 In this high-yield video, we simplify the mechanism of action of H2 receptor blockers like Ranitidine, Famotidine, Nizatidine, and Cimetidine, which act via competitive, reversible inhibition of H2 (Gs-coupled) receptors located on gastric parietal cells. The downstream effect is a decrease in cAMP, reduced protein kinase A activity, and ultimately, suppression of H⁺/K⁺ ATPase activity, leading to reduced gastric acid secretion (↓ HCl) 🧫.

Cimetidine, the oldest in this class, is infamous for its antiandrogenic side effects such as gynecomastia, low libido, and erectile dysfunction, and also causes CNS symptoms like confusion and dizziness due to its ability to cross the blood-brain barrier 🧠. It is a known CYP450 inhibitor, leading to significant drug interactions, especially with agents like clopidogrel. 📉 Other H2 blockers like famotidine and ranitidine are better tolerated, with far fewer side effects.

These drugs are used in the management of peptic ulcers, GERD 🔥, gastritis, and even in anaphylaxis alongside H1 blockers. 🚑 However, cimetidine is relatively contraindicated in pregnancy and lactation due to its ability to cross the placenta and be excreted in breast milk. Pro-tip for exam takers: "Drink a glass of H2O before dining 🍽️" — because H2 blockers are most effective when taken before meals. A must-watch for mastering this vital class of acid-suppressing drugs! 📚💯

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