GHB overdose: Features and Management

Описание к видео GHB overdose: Features and Management

GHB is used recreationally, but also as a date-rape drug. GHB overdose is a common emergency department presentation.

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Please note, this video is not medical advice

GHB toxicology is mediated largely through GABA receptors. Treatment for GHB overdose is mainly supportive. Aim to manage the airway conservatively as recovery will likely be rapid and spontaneous.

References:
Wood DM, Brailsford AD, Dargan PI. Acute toxicity and withdrawal syndromes related to γ-hydroxybutyrate (GHB) and its analogues γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD). Drug Test Anal. 2011 Jul-Aug;3(7-8):417-25. doi: 10.1002/dta.292. Epub 2011 May 6. PMID: 21548140.

Roberts DM, Smith MW, Gopalakrishnan M, Whittaker G, Day RO. Extreme γ-butyrolactone overdose with severe metabolic acidosis requiring hemodialysis. Ann Emerg Med. 2011 Jul;58(1):83-5. doi: 10.1016/j.annemergmed.2011.01.017. Epub 2011 Mar 24. PMID: 21435738.

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