Squamous Carcinoma Progression modeling through Coculture System | Protocol Preview

Watch the Full Video at https://www.jove.com/v/60644/multidim....

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression - a 2 minute Preview of the Experimental Protocol

Shuang Chen, Andreas Giannakou, Jonathon Golas, Kenneth G. Geles
Pfizer Worldwide Research and Development, Oncology R&D group;

An in vitro model system was developed to capture tissue architectural changes during lung squamous carcinoma (LUSC) progression in a 3-dimensional (3D) co-culture with cancer-associated fibroblasts (CAFs). This organoid system provides a unique platform to investigate the roles of diverse tumor cell-intrinsic and extrinsic changes that modulate the tumor phenotype.

Visit https://www.jove.com?utm_source=youtube&utm_medium=social_global&utm_campaign=reseach-videos-2022 to explore our entire library of 14,000+ videos of laboratory methods and science concepts.

JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching.

Subscribe to our channel:    / jovejournalofvisualizedexperiments