Tissue Plasminogen Activator (tPA) - Uses - Hematology - Pharmacology

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►👨‍🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Tissue plasminogen activator (tPA) converts plasminogen into plasmin, then plasmin will dissolve the fibrin clot into degradation produts “i.e. fibrinolysis”.

This is known as thrombolytic therapy, useful for myocardial infarction and ischemic strokes, but contraindicated in hemorrhagic strokes (due to increased risk of bleeding).

There are absolute contraindications as well as relative contraindications to fibrinolytic therapy (tPA, alteplase, streptokinase,...etc).

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