Xenobiotic Metabolism || Detoxification - Phase I Reactions || Biochemistry || Part 01

Xenobiotic Metabolism and Detoxification - This video is on the Metabolism of Xenobiotics , Phase 1 Reactions of Detoxifications with the role of Cytochrome P450 along with NEET PG MCQs.
Definition of Xenobiotics - 01:10 minutes
Detoxification and Biotransformation - 01:45 minutes
Mechanism of Detoxification of Xenobiotic - 02:33 minutes
Phase 1 and Phase 2 Reactions - 03:02 minutes
Cytochrome P450 - 03:51 minutes
Phase 1 reactions Oxidation - 06:34 minutes
Reductions - 08:37 minutes
Hydrolysis - 09:11 minutes
NEET PG MCQs - 10:14 minutes

Certain unwanted and harmful chemical agents may enter the human body through various routes such as inhalation, ingestion, skin contact, etc.
Most of these foreign compounds are subjected to metabolism (chemical alteration) in the human body.
In the past the metabolic processes that lead to the disposition of foreign compounds have been referred to as detoxification mechanisms.
MECHANISM OF DETOXIFICATION OF XENOBIOTICS
The liver is the principal organ responsible for detoxification of xenobiotics.
The pathways for hepatic detoxification include either:
1. Oxidation
2. Reduction
3. Hydrolysis
4. Conjugation
5. Some combinations of all these metabolic reactions

However, the term is not always appropriate because the detoxified products are sometimes more toxic than the original substance.
Biotransformation has been suggested as a preferable term
These foreign compounds are known as xenobiotics (Greek, Xenos = stranger).

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