The Gut's Role in Poultry Health and Disease

Optimal gut health is of vital importance to the performance of commercial poultry production. There is a direct relationship between bird performance and a “healthy” intestinal tract, with the gut responsible for regulating physiological homeostasis that provides the animal the ability to withstand infectious and non-infectious stressors. Gut health encompasses a number of physiological and functional features, including nutrient digestion and absorption, host metabolism and energy generation, a stable microbiome, mucus layer development, barrier function, and mucosal immune responses all of which are required to interact together so that the bird is able to perform its physiological functions to perform as close to 100% of its genetic potential. Comprehension of gut health requires the elucidation of the interactions between all of these components. Understanding the interactions between these diverse physiological features emphasizes the extent of areas encompassed by gut health and the ability to regulate poultry production. Thus, understanding gut health has been a primary focus of the poultry industry worldwide as a means of increasing production of meat and eggs, reducing the use of antibiotics, and enhancing animal welfare.

Dr. Kogut is a Research Microbiologist and Lead Scientist at the Southern Plains Agricultural Research Center, College Station, TX. Dr. Kogut has published over 220 peer-reviewed scientific papers, 19 book chapters, and has received 5 patents. Dr. Kogut’s research has concentrated on the development of cost-effective immunological interventions to improve gut health by studying the role of the microbiota in immunity to infection; the role of dietary metabolites in promoting immune regulation and immune responses to pathogens; characterizing novel molecular targets that mediate the actions of dietary compounds in inflammation and immunity; and understanding the integration of central metabolic pathways and nutrient sensing with antimicrobial immunity.