Скачать или смотреть Introduction to Azoles as Group of Antifungal drugs ; Mechanism of action, Classifications, Uses

Azoles are a widely used class of antifungal drugs that function by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. Without ergosterol, the structural integrity of the fungal membrane is compromised, leading to cell death. Azoles have a broad spectrum of activity against a variety of fungal pathogens, making them a cornerstone in antifungal therapy.

Classification of Azoles
Azoles are broadly divided into two subgroups:

Imidazoles: Examples include ketoconazole, clotrimazole, and miconazole. These are often used for treating superficial fungal infections.

Triazoles: Examples include fluconazole, itraconazole, voriconazole, and posaconazole. These are more commonly used for systemic fungal infections.

Applications
Azoles are used in treating conditions like:

Superficial infections: Athlete's foot, ringworm, and oral thrush.

Systemic infections: Candidiasis, cryptococcal meningitis, and aspergillosis.

Benefits
Broad-spectrum activity.

Availability in various forms: oral, topical, and intravenous.

#Antifungal