Скачать или смотреть Why Do We Use Glass Vials? Doctor Explains

Why Do We Use Glass Vials? Doctor Explains. Sources- PMID 38880302 PMID 30005987 anim0007gt on TT In pharmaceutical science, the transition from standard multi-dose vials to specialized glass ampoules is a critical safety measure for medications that are chemically reactive or biologically unstable. While standard vials use a rubber stopper for access, these stoppers can be a source of "leachables"—chemicals like plasticizers, vulcanizing agents, or latex that slowly migrate from the rubber into the medicine over time. For highly sensitive drugs, even microscopic amounts of these contaminants may alter the drug’s molecular structure or trigger an allergic reaction in the patient. By using an all-glass ampoule, the medication only comes into contact with borosilicate glass, an inert material that does not react with chemicals, ensuring the purity of the drug remains uncompromised throughout its shelf life. The most significant advantage of the glass ampoule is its hermetic seal, which is achieved by melting the glass neck shut with a flame. Unlike a rubber seal, which is microscopicially porous and can allow oxygen or moisture to slowly seep in, a flame-sealed ampoule is 100% airtight and gas-impermeable. This is a lifeline for "oxygen-sensitive" medicines that would otherwise oxidize and lose potency within hours of exposure to air. Furthermore, the design is inherently tamperproof; because the glass must be physically snapped to access the liquid, it is impossible to withdraw or alter the medication without leaving obvious, irreversible evidence of entry. This "one-and-done" single-dose format guarantees that every time an ampoule is cracked, the provider is delivering a sterile, full-potency dose exactly as the manufacturer intended. #meds #health #hospital