एंटीबायोटिक | Tazar 4.5g injection Uses | Pipzo 4.5g injection | Tazar Injection | Piperacillin 4.5g

एंटीबायोटिक | Tazar 4.5g injection Uses | Pipzo 4.5g injection | Tazar Injection | Piperacillin 4.5g



About this video and disclaimer -

*Tazar 4.5g Injection* is a combination antibiotic commonly used to treat a variety of bacterial infections. It contains *Piperacillin (4g)* and *Tazobactam (0.5g)* as its active ingredients. Here's a detailed overview:

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*Composition*
1. **Piperacillin**: A broad-spectrum penicillin antibiotic that kills bacteria by interfering with their cell wall synthesis.
2. **Tazobactam**: A β-lactamase inhibitor that protects Piperacillin from being destroyed by bacteria that produce β-lactamase enzymes.

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*Mechanism of Action*
Piperacillin kills bacteria by disrupting the bacterial cell wall.
Tazobactam inhibits the β-lactamase enzymes produced by resistant bacteria, enhancing Piperacillin’s effectiveness.

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*Dosage*
**Usual Dose**: 4.5g administered intravenously every 6-8 hours, depending on the infection's severity.
Dosage adjustment may be needed for patients with *renal impairment* or severe liver dysfunction.
Always follow a doctor's prescription.

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*Administration*
Administered as an *intravenous (IV) infusion* over 30 minutes or as a slow IV injection.
It should be reconstituted with a suitable diluent (e.g., sterile water for injection or saline).

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*Contraindications*
Hypersensitivity to penicillins, cephalosporins, or any other β-lactam antibiotics.
Severe renal impairment (dose adjustment required).

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*Side Effects*
Common side effects include:
Nausea, vomiting, or diarrhea
Rash or itching
Injection site reactions (e.g., redness or pain)
Fever or chills

Rare but serious side effects:
Allergic reactions (e.g., anaphylaxis)
Clostridioides difficile-associated diarrhea
Liver enzyme abnormalities
Thrombocytopenia or neutropenia
Seizures (in patients with renal impairment or high doses)

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*Precautions*
1. **Renal Function**: Regular monitoring is required, especially in patients with pre-existing kidney problems.
2. **Liver Function**: Monitor liver enzymes during long-term therapy.
3. **Drug Interactions**: May interact with anticoagulants (e.g., warfarin), methotrexate, and aminoglycosides.
4. **Pregnancy and Lactation**: Use with caution; consult a doctor before administration.
5. **Superinfection**: Long-term use may lead to overgrowth of non-susceptible organisms.


*Brand Names*
Tazar is a brand name, but similar combinations are available under other names like **Zosyn**, **Pipzo**, etc.

For specific treatment guidelines, always consult a healthcare professional.




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