Digoxin Toxicity - Symptoms, Diagnosis & Treatment | Credihealth

Digoxin Toxicity - Symptoms, Diagnosis & Treatment | Credihealth

Digoxin toxicity is a potentially serious condition that can occur when there are excessive levels of the medication digoxin in the body. Digoxin is a cardiac glycoside primarily used to treat various heart conditions, including heart failure, atrial fibrillation, and other supraventricular tachycardias.

The signs and symptoms of digoxin toxicity may include:

Cardiac effects:
Bradycardia (slow heart rate)
Irregular heartbeats (arrhythmias)
Cardiac conduction disturbances
Gastrointestinal effects:
Nausea and vomiting
Abdominal pain
Diarrhea
Anorexia

Neurological effects:
Visual disturbances (blurred vision, yellow-green halos)
Confusion
Drowsiness
Headache
Dizziness
Weakness

Other effects:
Electrolyte imbalances (hypokalemia, hypercalcemia)
Increased risk of digoxin toxicity in patients with kidney dysfunction
The risk of digoxin toxicity increases with factors such as:

Excessive dosage of digoxin
Impaired kidney function (reduced clearance of digoxin)
Electrolyte imbalances (hypokalemia, hypercalcemia, hypomagnesemia)
Drug interactions (e.g., with diuretics, antiarrhythmics, antibiotics)
Advanced age
Low lean body mass

If digoxin toxicity is suspected, immediate medical attention is required. Treatment may involve discontinuing digoxin, administering digoxin-specific antibody fragments (Digibind) to bind and remove digoxin from the body, correcting electrolyte imbalances, and providing supportive care as needed.

Monitoring digoxin levels, adjusting dosages based on kidney function, and avoiding drug interactions are essential measures to prevent digoxin toxicity in patients receiving this medication.

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