Скачать или смотреть Introduction to the Endocrine System | Chapter 7 – Human Physiology (8th)

This chapter provides a comprehensive exploration of the endocrine system, the body's complex network of chemical signaling responsible for maintaining homeostasis and regulating long-term processes such as metabolism, growth, and reproduction,. It begins by defining hormones as chemical messengers secreted by specialized cells into the blood to act on distant targets at very low concentrations, distinguishing them from other signaling molecules like pheromones or cytokines,,. The text systematically classifies hormones into three main chemical groups: peptide and protein hormones, which are synthesized as inactive preprohormones, stored in vesicles, and act rapidly via membrane receptors and signal transduction systems; steroid hormones, which are derived from cholesterol, synthesized on demand, and typically transported by carrier proteins to influence gene expression through intracellular receptors; and amine hormones, derived from amino acids like tyrosine (forming catecholamines and thyroid hormones) or tryptophan (forming melatonin),,,,,. The summary details the control of hormone release through endocrine reflex pathways and negative feedback loops, emphasizing the critical role of the nervous system and neurohormones,,. Significant attention is given to the pituitary gland, distinguishing between the posterior pituitary (neurohypophysis), which releases hypothalamus-synthesized oxytocin and vasopressin, and the anterior pituitary (adenohypophysis), a true endocrine gland regulated by hypothalamic trophic hormones via the hypothalamic-hypophyseal portal system,,. The chapter outlines the specific functions of the anterior pituitary hormones—prolactin, growth hormone, TSH, ACTH, FSH, and LH—and explains the complex long-loop and short-loop negative feedback mechanisms that govern their secretion,,,. Furthermore, it analyzes hormone interactions at the target cell level, defining synergism (where the combined effect is greater than the additive sum), permissiveness (where a hormone requires the presence of another to exert its full effect), and antagonism (where hormones have opposing physiological actions),,. Finally, the text addresses the etiology of endocrine pathologies, categorizing them into hormone excess (hypersecretion), deficiency (hyposecretion), and abnormal tissue responsiveness (such as receptor down-regulation), while explaining how to use trophic hormone levels to diagnose primary, secondary, and tertiary disorders,,,.


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