Dr. Sorana Morrissy presented “How Genetics Impact your Child’s Brain Cancer Journey” as part of the Join The Movement to End Brain Tumours - National Conference, in Toronto, on Saturday, October 22, 2016.
Medulloblastoma is the most common childhood brain cancer, and despite very aggressive toxic therapy is a major cause of pediatric cancer death in Canada. Thus, innovative strategies are needed to improve the quality of life for families of children with brain tumours and to increase survival rates. Specifically, we hope to develop more effective, personalized, and molecularly targeted therapies, using information gained from genetic analysis of individual patient tumours. However, growing evidence from adult cancers suggests that different geographical areas within the same tumour are biologically very dissimilar, and that these regions can respond differently even to targeted treatments. Indeed, if a new drug is going to be effective in the clinic, it is paramount that we know if a target of that drug is present in all pieces of a tumour. Thus, we sought to evaluate the geographical differences in pediatric brain tumours by analyzing several biopsies from the same patient at the time of their surgery. Our results provide a new insight into whether biological pathways are geographically stable, and how many biopsies are required for a clinically-relevant genomic-based understanding of tumour biology.
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