Accelerating Immuno-Oncology Drug Discovery with MOA-Reflective, Functional Cell-Based Assays

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Today’s immuno-oncology programs predominantly target checkpoint and cytokine receptors; coupled with new-age T-cell and NK-cell engagers and Antibody-Drug Conjugates (ADCs). Often, mechanisms-of-action (MOAs) of such therapeutics can be complex and multifold; and attest the need for capturing the physiological significance. Here, we present an adaptive assay platform that enables the characterization of a diverse array of therapeutic MOAs. These are functional cell-based assays with high specificity, sensitivity, and robust dynamic range.

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