Скачать или смотреть Step 1 - Sepsis can cause O2 problems

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Sepsis leads to oxygen problems primarily due to widespread inflammation and impaired blood flow. During sepsis, pathogens trigger an exaggerated immune response, releasing pro-inflammatory cytokines. This causes vasodilation and increased vascular permeability, leading to hypotension and reduced tissue perfusion.

Additionally, the body's metabolic demands increase due to infection, but the impaired perfusion limits oxygen delivery to tissues. Moreover, sepsis can cause mitochondrial dysfunction, reducing the cells' ability to utilize oxygen effectively, even when it is available. This results in a state of hypoxia, where tissues are starved of oxygen, leading to cellular injury and organ dysfunction. Ultimately, the combination of poor blood flow, increased oxygen demand, and impaired oxygen utilization contributes to the significant oxygenation problems seen in sepsis.

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