Management of FLT3 positive AML with Dr. Alexander Perl

In this episode, we dive into the management of newly diagnosed and relapsed FLT3-positive AML with Dr. Alexander Perl.

Here are the shownotes:
1. Assessment of minimal residual disease in standard-risk AML
https://www.nejm.org/doi/full/10.1056...

2. RATIFY study: Midostaurin plus chemotherapy for AML with a FLT3 mutation
https://www.nejm.org/doi/full/10.1056...

3. QuANTUM-First trial: Quizartinib plus chemotherapy in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia (QuANTUM-First): a randomised, double-blind, placebo-controlled, phase 3 trial
https://www.thelancet.com/journals/la...

4. Benefit of high-dose daunorubicin in AML induction extends across cytogenetic and molecular groups
https://ashpublications.org/blood/art...

5. Prospective Randomized Comparison of Idarubicin and High-Dose Daunorubicin in Induction Chemotherapy for Newly Diagnosed Acute Myeloid Leukemia
https://ascopubs.org/doi/10.1200/JCO....

6. Phase 3 trial of gilteritinib plus azacitidine vs. azacitidine for newly diagnosed FLT3mut+ AML ineligible for intensive chemotherapy
https://ashpublications.org/blood/art...

7. ADMIRAL: Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML
https://www.nejm.org/doi/full/10.1056...

8. Venetoclax Plus Gilteritinib for FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemia
https://ascopubs.org/doi/10.1200/JCO....

9. Levis MJ, Hamadani M, Logan B, et al: BMT-CTN 1506 (MORPHO): A randomized trial of the FLT3 inhibitor gilteritinib as post-transplant maintenance for FLT3-ITD AML. EHA 2023 Hybrid Congress. Abstract LB2711. Presented June 11, 2023.

10. Sorafenib maintenance in patients with FLT3-ITD acute myeloid leukaemia undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised phase 3 trial
https://www.thelancet.com/jo