Скачать или смотреть Journal Club | Visual Function with Aging in Normal and Alzheimer's Disease Model Mice

Striatech hosts a series of online Journal Clubs, highlighting the use and the applications of our devices. Scientists present their projects and new data, and you can learn about the latest developments in the field. There is always a Q&A session at the end.

Topic: "Visual Function with Aging in Normal and Alzheimer's Disease Model Mice"
Speaker: Anna Matynia, Ph.D. - University of Houston College of Optometry

Description:
Rod, cone and melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) are highly conserved from mouse to human. Consequently, many visual functions are highly translatable from bench to clinic, and are thus ideal for evaluating retinal function in aging and neurodegeneration such as Alzheimer’s Disease.

For example, ipRGCs have been shown to undergo early degeneration in mouse models of Alzheimer’s Disease, as well in human post-mortem retinas compared to aged controls.

Their contributions to visual acuity, contrast sensitivity and the pupillary light reflex can be differentiated in people and mice using behavioral assays that are non-invasive, amenable to repeated testing, with no to minimal collateral damage.

In this presentation, the effect of normal aging and Alzheimer’s Disease on visual acuity, contrast sensitivity and pupillary light reflex will be discussed as a possible early biomarker for Alzheimer’s Disease.

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