De novo design of miniprotein-based natural killer cell engagers

Описание к видео De novo design of miniprotein-based natural killer cell engagers

Presented on December 11th 2024 by Mireia Solà Colom

Abstract:
Immune cell engagers are a promising modality for cancer therapy, but many limitations must still be overcome before this approach will reach its full potential. De novo-designed miniproteins allow engineering high-valency immune cell engagers equipped with any imaginable functionality while allowing sophisticated control over on-cell binding, immune cell activation and immune synapse formation.

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