Metabolic Basis of Creatine in Health and Disease | Creatine Conference 2022

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Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target cells through a specific symporter called Na+/Cl−-dependent Cr transporter (CRT). Once within the cells, it seems that all the Cr-related system (known as the creatine kinase-phosphocreatine system) acts as a dynamic biosensor based on chemo-mechanical energy transduction. This system is physiologically essential for life (cell survival, growth, proliferation, differentiation, and migration/motility) by providing an evolutionary advantage for rapid, local, and temporal support of energy- and mechanical-dependent processes. This might explain why dysregulation in Cr metabolism contributes to a wide range of diseases besides the mitigating effect that Cr supplementation may have in some of these disease states.

In this talk, Prof. Diego A. Bonilla (Research Division, DBSS International) address the following questions:

(i) What happens when creatine is transported into cells?
(ii) How is the CK/PCr system involved in cellular bioenergetics?
(iii) How is the CK/PCr system compartmentalized throughout the cell?
(iv) What is the role of creatine amongst different tissues?
(v) What is the basis of creatine transport?

Access to the full article for free ⬇️⬇️
Bonilla, D. A., Kreider, R. B., Stout, J. R., Forero, D. A., Kerksick, C. M., Roberts, M. D., & Rawson, E. S. (2021). Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review. Nutrients, 13(4), 1238. https://doi.org/10.3390/nu13041238


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