Citoquinas (IL-1, IL-6 , TNF-alfa...). Aula 09 | Curso de Imunologia | Medicina passo a passo

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Description English: Three stages of immunopathological pathway leading to COVID-19 mortality. Stage I is Initiation, with an early induction of predominant chemokines upon SARS-CoV-2 infection and viral sepsis. Treatment at this stage with blocking agents to chemokines and emerging inflammatory cytokines is the key to prevent COVID-19 mortality. Stage II is Amplification, with large production of many more inflammatory mediators and massive recruitment of inflammatory cells to amplify immunopathological process. Stage III is Consummation, with continuous increases of inflammatory mediators and widespread organ damages.
Date 17 July 2020
Source Lu L, Zhang H, Zhan M, Jiang J, Yin H, Dauphars DJ, Li S-Y, Li Y and He Y-W (2020) Preventing Mortality in COVID-19 Patients: Which Cytokine to Target in a Raging Storm? Front. Cell Dev. Biol. 8:677.
https://doi.org/10.3389/fcell.2020.00677
Author Ligong Lu, Hui Zhang, Meixiao Zhan, Jun Jiang, Hua Yin, Danielle J. Dauphars, Shi-You Li, Yong Li, and You-Wen He