What cofactors are needed to synthesize and recycle BH4?

Question: What cofactors are needed to synthesize and recycle BH4?

Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR).

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*Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
*How Much Iron Can We Absorb At Once?

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This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

*Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
*How Much Iron Can We Absorb At Once?
*What nutrients are important for long-term PPI use?
*For how long does transferrin saturation respond to recent iron-rich food?
*Muscle spasms: creatine, creatinine, sodium, and potassium.
*Hematologists ignore iron saturation.
*How to detox arsenic?
*Could folic acid supplements impair BH4 recycling?
*How to increase butyrate?
*More on hematologists and transferrin saturation.

Here’s a link to the full AMA: https://chrismasterjohnphd.substack.c...

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