Скачать или смотреть Molecular Editing: Shaping the Future of Drug Discovery

Molecular editing is revolutionizing the way we design and develop new drugs! In this video, we explore how chemists can modify molecular structures with precision, leading to more effective and metabolically stable pharmaceuticals. From replacing benzene rings with bioisosteres like BCP to groundbreaking catalytic strategies for skeletal editing, molecular editing is shaping the future of medicinal chemistry.

We’ll break down key examples, including innovative approaches to ring expansion and contraction, and discuss how these methods improve drug properties. Plus, we’ll look at the latest research and how it’s driving the next generation of drug discovery.
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References:
Nat. Chem. 15, 535–541 (2023). Soumitra Agasti, Frédéric Beltran, Emma Pye, Nikolas Kaltsoyannis, Giacomo E. M. Crisenza & David J. Procter. A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres. https://doi.org/10.1038/s41557-023-01...
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Time Code:
00:00 - Intro
02:38 - Favorskii Rearrangement
03:18 - Benzilic Acid Rearrangment
04:32 - Bioisosteres of Benzene
04:59 - Antagonist of the Group I Metabotropic Glutamate Receptor
05:15 - γ-secretase Inhibitor
05:55 - Bicyclo[2.1.1]hexanes
06:09 - Valsartan
06:16 - Fluxapyroxad
06:28 - Catalytic approach