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Solas
Mebendazole USP
Description
Mebendazole (Solas) is a synthetic broad-spectrum anthelmintic that is active against most nematodes and some other worms. Mebendazole is principally used in the treatment of intestinal nematode infection.
Mode of action
Mebendazole inhibits the formation of the worms' microtubules and causes the worms' glucose depletion.
Pharmacokinetics
After oral administration about 2-10% of oral dose is absorbed from Gl tract and peak plasma concentration occurs within 0.5 to 7 hours. Mebendazole is highly bound to plasma protein. Elimination half-life is 2.8 to 9 hours.
Composition
Solas 100 mg Tablet: Each tablet contains Mebendazole USP 100 mg. Solas Suspension: Each 5 ml contains Mebendazole USP 100 mg.
Indications
Mebendazole is indicated for the treatment of threadworms, whipworms, roundworms and hookworms.
Dosage & administration
Adult and Child over 2 years
Worm
Dose
Frequency & Duration
Threadworms
100 mg or 1 teaspoonful
Single dose
Whipworms
Roundworms
100 mg or 1 teaspoonful
Twice daily for 3 days
Hookworms
if reinfection occurs second dose may be needed after 2 weeks.
Child under 2 years is not recommended.
Contraindications
Mebendazole is contraindicated in persons who have shown hypersensitivity to the drug.