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Video Summary:
It's recommended that you watch the first video on oxygen hemoglobin dissociation curve before starting this video. All the basic are covered in that video. In this video we are focusing on the shift in oxygen hemoglobin dissociation curve. This video is in two parts. First I have mentioned how the binding of oxygen with hemoglobin is affected with shift in the curve. Here I have avoided siting any examples. Then in second part, we will see factors that shift the curve. Here we have increased temperature, carbon dioxide, hydrogen ion and 2,3 DPG which shift the curve to left. Shift in curve to right by increased carbon dioxide and hydrogen is also called Bohr's effect. It helps deliver more oxygen to tissues. 2,3 DPG level is increased in hypoxia and it helps in adaptation to it. Carbon monoxide shifts the curve to left. It increases affinity of hemoglobin so much that hemoglobin don't release oxygen at peripheral sites, depriving the tissue of oxygen.

🎞More videos on Respiratory Physiology:
● Transport of Gases
Oxygen Hemoglobin Dissociation Curve:    • Oxygen Hemoglobin Dissociation Curve  
Factors Shifting Oxygen Hemoglobin Dissociation Curve:    • Factors Shifting Oxygen Hemoglobin Dissoci...  
Oxygen Hemoglobin Dissociation Curve during Exercise:    • Oxygen Hemoglobin Dissociation Curve durin...  
Transport Of Carbon Dioxide:    • Transport of Carbon Dioxide in blood  
Carbon Dioxide Dissociation Curve:    • Carbon Dioxide Dissociation Curve  
Haldane Effect:    • Haldane Effect in Transport of Carbon Dioxide  
● Lung Mechanics
Alveolar Pressure and Pleural Pressure:    • Alveolar Pressure and Pleural Pressure  
Surface Tension in Lung Alveoli:    • Surface Tension in Lung Alveoli  
Surfactants Mechanism of Action:    • Surfactants Mechanism of Action  
Functions of Surfactants:    • Functions of Surfactants in Alveoli  
Compliance of Lungs:    • Compliance of Lungs  
Diseases Affecting Lung Compliance:    • Diseases Affecting Lung Compliance  
• Ventilation & Dead Spaces in Respiratory Tract:    • Ventilation & Dead Spaces in Respiratory T...  
• Lung Volumes and Capacities:    • Lung volumes and capacities  
• What Determines Lung Volume?:    • What Determines Lung Volume?  

00:00 Introduction
00:21 What a shift means
02:38 Factors shifting the curve

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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.