Скачать или смотреть drug potency & binding energy

directory of Chem Help ASAP videos: https://www.chemhelpasap.com/youtube/

The potency of a molecule is normally reported through an IC50, EC50, Ki, or Kd value. For a drug, a typical potency is 10 nM (10e-8 M). Sometimes, potencies are reported in the form of pIC50 or pKi. pKi = -log Ki, so if Ki is 10 nM, then pKi is 8. In the case of Ki and Kd values, since these are equilibrium constants, they can be directly converted to binding energies through the equation deltaG = -2.3RT log (1/Ki) or deltaG = 2.3RT pKi. R = 0.0199 kcal/mol*K. T = 298 K. Using this formula, a typical drug has a binding energy of -10.9 kcal/mol. Actual binding energies will vary, but -11 kcal/mol is a representative number.