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What Were the Medical Problems, Height of Popularity, and Details of Death of Thomas Jefferson?

Question:
What were the medical issues faced by Thomas Jefferson, especially during his peak popularity, and what specific details can be shared about his death?

Answer:

Medical Problems During Height of Popularity (1801–1809, Presidency Years):

Chronic Diarrhea: This troubled him throughout his life, including his presidency.
Migraines: Debilitating migraines were frequent and likely impacted his ability to function fully at times.
Wrist Injury: Continued to suffer from complications from a previous wrist fracture.
Depression: Periods of depression were not uncommon, possibly exacerbated by the stresses of political life.
Signs of Aging: As Jefferson aged, he showed signs of wear and tear, possibly experiencing rheumatism and other age-related ailments.
Details of Jefferson's Death:

Date of Death: Jefferson died on July 4, 1826, the 50th anniversary of the Declaration of Independence.
Age at Death: He was 83 years old at the time of his death.
Cause of Death: Though the exact cause is debated, uremia from chronic kidney failure is often cited. This could have been exacerbated by infections, diabetes, or other underlying conditions.
Final Days: His death was preceded by prolonged suffering, including severe diarrhea, weakness, and confusion.
Last Words: His last recorded words were inquiries about the date, possibly aware of the approaching Fourth of July.
Place of Death: He died in his beloved home, Monticello, in Virginia.
Legacy: His death marked the end of an era, and his contributions to American democracy continue to be celebrated.