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Blood clotting, or coagulation, is a vital physiological process that prevents excessive bleeding when blood vessels are injured. This intricate mechanism involves the rapid response of platelets, which adhere to the site of injury to form a temporary plug, and a cascade of biochemical reactions among various clotting factors, leading to the formation of a stable fibrin mesh. The endothelium, or inner lining of blood vessels, plays a crucial role by normally producing substances that prevent clotting, but upon injury, it exposes tissues that trigger the clotting cascade. Proper regulation of this process is essential, as imbalances can lead to conditions such as excessive bleeding or thrombosis, where unwanted clots form in blood vessels. Understanding the intricacies of blood clotting is critical for the effective management and treatment of related medical conditions.

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