How Stem Cells Contribute to Aging and Age-Related Diseases with Rob Signer

What challenges does aging pose to both individuals and society at large? What causes aging at the cellular and molecular level? Stem cell research is be key to finding solutions that increase our healthspan and change how we think about aging. Robert A.J. Signer, Ph.D., shares what is on the horizon. [10/2022] [Show ID: 38215]

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0:00 Introduction
2:39 Aging is an Emerging Global Public Health Issue
4:06 Aging is Fundamentally Changing the Economy
8:26 Stem Cell Superpowers: Self-Renewal & Multilineage Differentiation
10:03 Aging Causes Stem Cells to Malfunction Leading to Degenerative Diseases
11:17 Aging of Blood-Forming Stem Cells Leads to Blood & Immune Disorders
16:49 Reducing Protein Synthesis Alleviates Stress
20:44 HSF1: An Alarm System for Misfolded Proteins
21:54 Aging Stem Cells Sound the Stress Alarm
22:55 Aging Stem Cells Accumulate Aggregated Proteins
23:24 A Double-Edged Sword: HSF1 Also Protects Cancer Cells from Stress
24:23 Keeping Our Aging Stem Fells Fit Increases the Risk of Cancer
25:26 Limiting Misfolded Proteins to Keep Stem Cells Fit & Prevent Cancer
26:05 Strategy: Make Protein Synthesis Less Error-Prone
27:40 Keeping Stem Cells Fit to Extend Human Healthspan Aging is a primary risk factor for disease & death