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Another new PB, The main thing to get this working is doing enough DPS to kill Smith John before he applies Handcuffs to you.

Sasuke stats:
24.9% DMG
12.3% SPA
12.1% RNG

Familiars used:
12.9% Foo on aurin,
11.7 Second Padoru on Orehimi

I have damage indicators on to see when newsman and sasuke hit the boss for better timing.

Pre-wave 1:
Place 1 Newsman, 1 Armin, 1 Orihime.

Wave 1:
Wait for 5 enemies to spawn in,
Place Sasuke, upgrade to 2,
place joe in Cid,
Set sasuke Targetting to strongest/Bosses.

Pre-wave 2:
Place smith, put sword on sasuke
Place 2nd newsman, after the 1st has attacked to stagger bubble application.

Once John smith dies:
Sell 1 newsman

Once Lord of Shadows Spawns:
Place 1 Newsman after the 1st newsman has attacked
2/3 seconds later place 3rd Newsman

When you have enough money for Onyx Chidori,
Wait till after sasuke attacks the boss then upgrade to next attack to SPA reset him.

Lastly upgrade smith once and reapply the new sword to sasuke,
for the rest of the stage, upgrade sasuke when you can and do the number games.

The first phase is important to follow to ensure you can skip the first handcuffs on the smith john phase.