A Pyridine Dearomatization Approach to the Matrine-type Lupin Alkaloids with Jeff Kerkovius

In this Research Spotlight episode, Jeff Kerkovius (Reisman group, Caltech) takes us through his work on a pyridine dearomatization approach to the synthesis of matrine-type lupin alkaloids.

Key reference:
J. Am. Chem. Soc. 2022, 144, 15938-15943.
https://doi.org/10.1021/jacs.2c06584

Additional references (in order of appearance):
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Nat. Prod. Rep. 2022, 39, 1423–1437.
Ohmiya, S., Saito, K., Murakoshi, I. The Alkaloids: Chemistry and Pharmacology; Cordell, G. A., Ed.; Academic Press, 1995, 47, 1–114. Front. Pharmacol. 2020, 11, 588.
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Chem. Pharm. Bull. 1975, 23, 2560–2566.
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Chem. Pharm. Bull. 1975, 23, 2560–2566.