Скачать или смотреть D-218 | Antileprotic Drugs (Chemical, SAR, Synthesis & Metabolism)- Pharmacology | Rapid Revision

This topic focuses on antileprotic drugs used in the treatment of leprosy (Hansen’s disease). The main drugs include dapsone, rifampicin, and clofazimine, commonly used in multidrug therapy (MDT). Chemically, dapsone is a sulfone derivative, and its antibacterial activity is related to structural similarity with PABA (antifolate action). Rifampicin inhibits RNA polymerase, while clofazimine interferes with mycobacterial DNA and has anti-inflammatory action. Dapsone undergoes acetylation in the liver, and understanding SAR, mechanism, and metabolism is important for medicinal chemistry and pharmacology— specially designed for quick revision before exams.
🎯 Highly useful for GPAT, NIPER, Drug Inspector, Pharmacist & other Govt. Pharmacist exams.
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