Webinar 14: Huntingtin aggregates trigger an immune response

In this session: Miguel Aguileta discusses that Huntingtin (HTT) aggregates induce an immune-like response in a cell model. The presence of HTT aggregate is a well-established hallmark of Huntington’s disease. Specifically, they developed a method to separate cells that originate from the same clonal cell-line but that form or not protein inclusions with a disease mutant form of HTT. Using this method, Miguel performed label free proteomics, and discovered that cells with HTT-positive inclusions responded similarly to cells infected by viruses, based on the proteins that were expressed at higher levels. Notably, the cells with aggregates expressed specialized proteins that participate to the presentation of antigens at the cell surface.

Webinar 14_280520.