Скачать или смотреть Kavli Exploration Award | The effects of hypoxia on neural RNA editing

Cephalopods like squid, octopus, and cuttlefish have the largest brains among invertebrates and demonstrate extremely high intelligence and behavioral complexity. Researcher Joshua Rosenthal at the Marine Biological Laboratory, along with collaborators Eli Eisenberg at Tel Aviv University, Emma Hammarlund at Lund University and Matthew Birk at St. Francis University, are studying how these creatures adapt to environmental changes. In previous work, they discovered that cephalopods use a genetic process to modify neural proteins, called RNA editing, which helps them rapidly adjust to different conditions such as environmental temperature changes. Now, these investigators will explore the role of this process with other environmental perturbations that may impact cephalopod neurophysiology and behavior. This global group of investigators will explore how RNA editing is involved in cephalopods’ ability to tolerate low oxygen levels, which occurs frequently in nearshore waters because of agricultural and effluent wastes. Understanding neural adaptability to oxygen levels is a crucial factor for cephalopod survival in the face of aquatic pollution and may shed light on other ways that oxygen levels and brain function are linked.   

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